Sentence examples for hepatic pathologic from inspiring English sources

This vaccine candidate was also safe and immunogenic in humans, yet caused elevation in levels of liver enzyme activity and hepatic pathologic changes in both marmosets and chimpanzees.

LA-1 (104.5 - 5.5 TCID50) injected by iv into marmosets (Saguinus mystax), caused a mild and transient elevation of liver enzyme activity in 3 of 6 animals, but not in the 30 human volunteers who had received the same virus strain by intramuscular injection ; similarly, no hepatic pathologic change was found in the marmosets and all animals seroconverted to neutralizing antibody.

The relationship between apoptosis and pathologic hepatic fibrosis has been appreciated in recent years.

Other exclusion criteria were sepsis, left ventricular dysfunction, cardiac arrhythmia, peripheral arterial disease, haemoglobin level of less than 8 g/dl, renal or hepatic failure, and all pathologic conditions known to be associated with microcirculation abnormalities.

Importantly, over-expression of mLDLR did not result in the pathologic accumulation of hepatic cholesterol (Fig. 3D) or hepatic triglycerides (Fig. 3E) at any of the doses examined.

In addition to staging hepatic fibrosis for viral hepatitis, three pathologic criteria have been used for patients with NAFLD.

We investigated the functional role of histone demethylase JMJD2B in the pathologic regulation of hepatic steatosis.

This finding occurs more often in larger than smaller hepatic lesions, suggesting that intrinsic pathologic characteristics such as tumour growth or fibrosis, rather than tumour response alone, may contribute to capsular retraction [19].

Principal inclusion criteria were: diagnosis of active hepatitis of any etiology plus clinical or pathologic diagnosis of cirrhosis or hepatic fibrosis (any stage); no evidence liver tumor on ultrasound or cross-sectional imaging within 6 months; AFP ≤ 20 ng/mL within 6 months; ≥ 6 weeks post biopsy, surgery, or other invasive procedures; no prior history of HCC.

Accumulating evidence from animal models and from patient data suggests that deregulation of activin A signaling contributes to pathologic conditions such as hepatic inflammation and fibrosis, acute liver failure, and development of liver cancer.

A central feature of this pathologic response is insufficient hepatic insulin action, due to a combination of insulin resistance and impaired β-cell function.