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Hepatic parameters were not affected.
Patients were excluded from the study if they had significant weight loss in the preceding 6 months (n = 4), or if they were taking medications that could affect metabolic and/or hepatic parameters (n = 9).
Secondary safety outcomes included the occurrence of SAEs until 10 months post Dose 3, unsolicited AEs after each vaccination over a 30 day follow-up period (day of vaccination and 29 subsequent days), solicited general and local reactions over a 7 day follow-up period (day of vaccination and 6 subsequent days) after each vaccination, abnormal hematological, renal, and hepatic parameters.
Hepatic parameters remained stable overtime apart from TB, as expected.
No significant changes in platelets or hepatic parameters were observed.
There were no significant changes in renal or hepatic parameters.
Similar(38)
Prediction of 28-day mortality by SOFA could not be improved by models including any hepatic parameter.
Although no dose response is observed in bilirubin and alkaline phosphatase levels with urinary arsenic content compared to unexposed group, the significant increase in levels of other hepatic parameter indicates that increase in arsenic exposure causes hepatic injury since all the parameters together contribute to hepatic damage.
Finally, for all of the subjects with clinically significant elevations in their hepatic biochemistry parameters, the values of those parameters fell below the ULN by the end of the study; typically, the elevations resolved within 10 to at most 30 days.
Doppler ultrasonography is a non invasive method to measure Doppler hepatic hemodynamic parameters.
Accuracy of the hepatic hemodynamic parameters to predict SLD was measured by the area under the ROC curve.
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