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All five patients with NICCD had infant hepatitis syndrome at diagnosis, presenting with jaundice and abnormal hepatic function tests, though all developed well with normal hepatic function tests after treatment.
No significant difference was observed in the hematological parameters and renal and hepatic function tests.
Urinalysis and renal and hepatic function tests were essentially within normal limits in our series.
The results of electrolytes and renal and hepatic function tests were normal.
Abnormalities in hepatic function tests were frequently observed, especially on DL 1.
Chest X-rays (CXR) were also undertaken, as were hepatic function tests serum AST and ALT.
Similar(36)
Selection criteria were based on normal complete blood test results, renal and hepatic function test results, and radiography and ultrasonography findings.
Baseline evaluations included physical exam, serum chemistries, hepatic function testing, complete blood counts, and computed tomography or magnetic resonance imaging at the discretion of the treating physician.
Hepatic function testing showed significant grade I and II alanine aminotransferase (ALT) elevations (P < 0.001) and grade I aspartate aminotransferase (AST) elevations (P < 0.001) during posaconazole treatment respective to baseline.
Inclusion criteria for participants were 2-fold: a) only clinically healthy males with normal hepatic function test values were included, and b) only those not taking drugs that alter CYP2E1 activity (e.g., acetaminophen, isoniazid, disulfiram, chlormethiazole, or chloroquine) were included (Frye and Branch 2002; Park et al. 1993; Simi and Ingelman-Sundberg 1999).
Laboratory investigations in the form of complete blood counts, renal and hepatic functions tests, serum parathormone level, serum electrolytes, alkaline phosphatase, random blood sugar, and Hepatitis C virus antibodies were collected from the most recent data in the patients' files and were repeated when necessary.
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