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Hepatic abnormality has been reported in the embryo of both IRE1α KO mice and XBP1 KO mice [19], [21].
The δ-SG was expressed in the liver of some animals injected with serotype 2/8, but this expression did not cause any apparent hepatic abnormality at the histological level (not shown).
It is estimated that about 60.5% of patients with hyperthyroidism exhibited at least one hepatic abnormality upon diagnosis [ 13].
Obese asymptomatic subjects were well characterized in order to exclude any hepatic abnormality, and pharmacodynamic data were obtained in rigorous conditions using continuous monitoring of gastric pH.
Non-alcoholic fatty liver disease, a disorder that encompasses a wide spectrum of hepatic abnormality from fatty infiltration and steatosis to steatohepatitis, fibrosis and ultimately cirrhosis, is increasingly recognised to be associated with the diabetic condition, potentially affecting up to 90% of people with established type 2 diabetes [ 5- 7].
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However, it is conceivable that the primary cause of IPH is not related to hepatic abnormalities but rather to abnormal splenic perfusion.
Despite marked increases in hepatic glycogen accumulation, the AAV-LL mice display no evidence of hepatic abnormalities, hepatic steatosis, or HCA.
To determine whether abdominal magnetic resonance imaging (MRI) detects hepatic abnormalities before clinical or biochemical perturbations in patients after the Fontan procedure.
Our results demonstrate for the first time the effectiveness of mRNA therapy as a potential treatment in reversing the hepatic abnormalities associated with GSD1a.
In the present study, hepatic abnormalities were not found on analysis of IRE1α CKO mice.
There were no significant or notable hematologic, renal, or hepatic abnormalities in any of the subjects at any time during the study.
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