We also consider the effect of the asymmetry γ of the DES in the GIS that is limited by the manufacturing technology of the sensor and hence making it difficult to reduce further.
Conventional frequency response estimation methods such as the "H1" and "H2" methods often yield measured frequency response functions which are contaminated by the presence of non-linearities and hence make it difficult to extract underlying linear system properties.
A main disadvantage of the ROCE metric is the lack of a well-defined upper boundary, hence making it difficult to compare the quality of underlying models and applied cutoff thresholds.
The 'Security analysis' section gives the statistical analysis of the proposed image encryption scheme, which increases the complexity of the random bit generation and hence making it difficult for an intruder to extract information about the proposed encryption/decryption hyperchaotic modulation.
Unfortunately, this study analyzed a relatively small number of sequence variants in the DR4 apoptosis-related gene; hence, making it difficult to compare study findings.
Neurodegenerative diseases such as Parkinson's (PD), Alzheimer's disease (AD), or amyotrophic lateral sclerosis (ALS), are generally complex (Box 1), hence making it difficult to choose a single gene to target, – although several trials are in development (Table 1).
In addition, if a major medical complication occurs during the first stage of surgery, this patient may be medically unfit to undergo the second stage of surgery, hence making it difficult for a direct comparison with a suitable control group.
Mobile telephones are the opposite; they are rarely listed (7.3% of mobile telephone users found in this study) and the number structure does not provide any details of geographical location, hence making it difficult to generate a sampling frame similar to current cost effective RDD methods.
The HCPs expressed that patients might see a different doctor for their next follow-up, hence this makes it difficult for them to manage these patients' falls, which should be monitored from baseline.
Hence, although heterogeneity makes it difficult to draw firm conclusions, there is evidence that subjects with atherosclerotic disease are at an increased risk for frailty fractures.
