The human vitamin D receptor (hVDR) is a member of the nuclear receptor superfamily, involved in calcium and phosphate homeostasis; hence implicated in a number of diseases, such as Rickets and Osteoporosis.
Only a restricted few are exclusively assigned to macrophages and are hence implicated in specific macrophage functions.
This identified a number of genes that are regulated in OA, which are hence implicated in the disease process.
Most interestingly, some miRNAs showed higher expression levels in urine compared to serum, hence implicating particular miRNA secretion processes in kidney and/or urothelial compartments [ 50].
Our earlier work profiling these gene families in cartilage identified a number of genes that are regulated in OA, which are hence implicated in the disease process.
They were more rapidly taken up by the MDR cells and this uptake was reversed after quinacrine treatment back to the rates observed with the parental cell line, hence implicating quinacrine in reversing the MDR [ 174].
Furthermore, we found that serum-depleted culture conditions, but not acidic conditions, significantly upregulated CD26 levels, hence implicating a potential role for nutrients or serum growth factors in the regulation of CD26 protein expression.
The newly discovered role for the redox regulation of cathepsin B in this study hence implicates the potential importance of redox modulation of cysteine protease activity as a means of arthritis treatment.
UDP-glycosyltransferases (UGTs) use UDP-activated sugars as donor to catalyse the glycosylation of various metabolites and are hence implicated in a series of mechanisms and pathways, including phase II of the detoxification mechanism.
This new structure made it possible to distinguish between primary care, provided routinely for diagnosis and follow-p by the GP, the gynaecologist and the radiologist, and secondary care providing treatment of the cancer and hence implicating the surgeon and the oncologist.
