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This result could be due to the excess of modified starch in the system, which caused bridging flocculation and hence destabilizing the emulsion system [4, 40].
To date, lack of myogenic differentiation of PAX3-FOXO1 expressing ARMS cells has been attributed to their inability to upregulate p57Kip2 activity, hence destabilizing the DNA binding affinity of MYOD transcription complexes.
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In the case of the multiloop there is also no problem as long as one is only interested in energy minimization, since multiloops are always destabilizing and hence have strictly positive energy contribution.
The following structural motifs are destabilizing and hence can be excluded: (i) addition to adjacent carbon atoms; (ii) addition to THJ carbon atoms; (iii) addition of more than one CF3 group to one pentagon.
With changes in thermodynamic conditions such as pressure, temperature, and crude oil composition, stable dispersion of asphaltenes in crude oil would be destabilized; hence, asphaltenes precipitate out of the crude oil solution and settle in the form of solid deposits which can impede the production process (Shirani et al. 2012a, b).
Hence, R641H substitution destabilizes the fold owing to the smaller and lesser charged histidine side-chain which cannot reach out to D709 to form a salt bridge.
Hence, it would destabilize the nucleosome in a way that could be reminiscent of that caused by mouse brain H2A.Z.2.2 [ 7].
A very specific role for the Microprocessor in destabilizing Dgcr8 and hence providing a negative feedback on Microprocessor levels itself suggests that homeostatic control of microRNA processing is central to normal cellular physiology.
Hence, this implies that by destabilizing the initial attractor and stabilizing the final one, one can induce the required transitions.
Interestingly, UpA dinucleotides are sites for preferential hydrolysis of RNA by macrophage ribonucleases [45] destabilizing RNA molecules [7] and should hence be avoided [45].
Hence the absence of autophagy causes a vast accumulation of both destabilizing the cell.
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