Sentence examples for hence alteration from inspiring English sources

Hence, alteration of GS level by modifications of its transcription and/or degradation rate constitutes a novel form of regulation of the glycogen metabolism.

Hence, alteration of the histidine domain of Aβ prevented neuronal binding and drove Aβ to enhanced fibril formation and subsequent amyloid plaque deposition - a potential mechanism for removing toxic species of Aβ.

Hence, alteration of surface membrane microdomain lipid and protein composition via inhibition of syntaxin-6 function was found to decrease the internalization of cargo molecules by caveolae [ 61].

Hence, alteration (e.g., activation and inactivating mutations) of genes (e.g., PTEN, KRAS, and LKB1) whose products regulate the mTOR axis will result in hyperactivation of the axis in certain types of cancers.

TACC3, in complex with the Ch-Tog protein, is essential in spindle microtubule growth and stability [ 14, 49]; hence, alteration of TACC3 localization following MK-0457 treatment could explain, at least in part, the aberrant spindle formation in TT cells.

Nevertheless, as mentioned, aging is a multifaceted phenomenon and hence alteration in stem cells, their niche, systemic cues that regulate stem cell activity, the gender of patients (Hardman and Ashcroft, 2008) converge together, leading to a deficient skin healing in elderly burn patients compared with young adults.

Hence, alterations in host preference are associated with changes in development, regulation and function at the olfactory periphery.

Hence, alterations in both hydrological and geotechnical conditions result, changing the triggering thresholds for further failure.

Hence, alterations in deiodinase balance can affect downstream tissue-specific TH signaling and local action.

Hence, alterations in the DDR pathways may accumulate these lesions to trigger hepatocarcinogenesis and also to facilitate advanced HCC progression.

We hypothesized that alterations in mRNA abundances (and hence alterations in functional profiles) are regulated, in part, by specific transcription factors.