All potential end points and hemorrhagic events (gastrointestinal bleeding and hemorrhagic stroke) were adjudicated by an independent committee that was blinded to the group assignments.
Secondary end points included hemorrhagic stroke, all-cause mortality, and a composite end point (thromboembolism, hemorrhagic stroke, or all-cause mortality).Among 10 524 patients undergoing surgery (median age, 76 years; 39% female; median CHA2DS2-VASc score, 4), 3892 (37%) underwent S-LAAO.
A large number of animal models have been developed to simulate the critical end-points of hemorrhagic shock.
Although these techniques may move the end-points of hemorrhagic shock to the organic, cellular, and subcellular levels, large clinical studies are scarce.
Transcranial Duplex-assessed resistance to MCA recanalization and symptomatic hemorrhagic transformation were considered secondary end points.
*TMC, Troop Medical Clinic; HFRS, hemorrhagic fever renal syndrome; FP, firing point; TBTA, Twin Bridges Training Area; S, south; N, north.
It would be ideal to measure O2D at the cellular level as an end-point of experimental and clinical hemorrhagic shock.
The primary analysis used the Antiplatelet Trialists' Collaboration end points, which include: (1) cardiovascular, hemorrhagic, and unknown deaths, (2) nonfatal myocardial infarction, and (3) nonfatal stroke.
Table 1 summarizes the historical development of hemorrhagic shock models with O2D as an end-point.
The primary end point was an in-hospital morbidity profile; secondary end points were clinical and angiographic potency and hemorrhagic events.
