A review team comprised of experts from multiple fields (hematology, critical care, research methodology and library sciences) formulated the research question, reviewed the search strategy and review methods, and provided input throughout the review process.
At the drug giant Amgen, where Begley was vice-president and global head of hematology and oncology research, he was struggling to repeat an animal study of tumor growth by a respected oncologist, published in Cancer Cell.
When he returned in 1945, they moved to Boston where he completed a chief residency at the Beth Israel Hospital and pursued research in hematology.
The groom, 29, is a third-year resident in internal medicine at Massachusetts General Hospital in Boston, where he does research in hematology and oncology, focusing on the treatment of leukemia.
Continued development of in-vitro procedures for expansion and differentiation of erythroid progenitor cells (EPC) is essential not only in hematology and stem cell research but also virology, in light of the strict erythrotropism of the clinically important human parvovirus B19.
After completing their specialty clinical training (e.g., in medicine or pediatrics), most physician-scientists pursue subspecialty clinical training (e.g., cardiology or hematology-oncology) and postdoctoral research that typically combines protected research time with intensive clinical training.
His early research interests included hematology and poliomyelitis.
In a recent review of best practice and research in clinical hematology [ 8], it was noted that iron uptake into developing erythroblasts begins at an early stage and is completed before late erythroblastosis.
A cancer expert not involved with the study, Dr. Stephen Nimer, chief of the hematology service at Memorial Sloan-Kettering called Centhe, called the research a "tour de force" and the report "a wonderful paper".
