Blood collected in the tubes with K3-EDTA was used for hematology examination, performed with an Abacus Junior Vet Hematologic Analyzer Diatron Groupp, Budapest, Hungary).
These properties then resulted in the remarkable in vivo antitumor effect of SMA-THP conjugate without apparent toxicity (Figs 6), which was also supported by the results of hematology examination and liver, heart, and kidney functions (Table 1).
On days 1 and 4, blood and urine samples were collected for analysis of fenitrothion and its major metabolites, as well as plasma and red blood cell cholinesterase activities, and biochemistry and hematology examination.
All clinical chemistry and hematology laboratory examination sub processes or process maps were designed.
Hematological examinations were performed using a Coulter AcT Diff hematology analyzer (Beckman Coulter, Inc., Brea, CA, USA) or a HEMAVET 950 multispecies hematology instrument (DREW Scientific, Inc., Dallas, TX, USA).
Outcome measures included body mass, weight gain, results of clinical examination, hematology and plasma chemistry.
During the subchronic oral toxicity study, no mortality and toxicologically significant changes in clinical signs, food consumption, opthalmoscopic examination, hematology, clinical biochemistry, macroscopic findings, organ weights and histopathological examination were noted in animal administered diet containing bruchid-resistant mung bean.
During the 6-month treatment period and one month recovery period, no mortality and toxicologically significant changes in clinical signs, opthalmoscopic examination, hematology, clinical biochemistry, serum sex hormone, macroscopic findings, organ weights and histopathological examination were noted and attributed to naringin administration.
During the subchronic oral toxicity study, no mortality and toxicologically significant changes in clinical signs, food consumption, opthalmoscopic examination, hematology, clinical biochemistry, serum sex hormone, macroscopic findings, organ weights and histopathological examination except for slight body weight decrease were noted and attributed to naringin administration.
Other baseline measurements included physical examination, hematology, and biochemistry.
Physical examination, hematology and blood chemistry analysis were performed weekly.
