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Figure 2 Blood hematology analysis of rats treated with C-dots.
Using a standard saphenous vein blood collection technique, blood was drawn for hematology analysis (using potassium-methylenediaminetetraacetic acid collection tubes).
Safety monitoring included the recording of adverse events, changes in vital signs, physical examination, electrocardiogram, and laboratory parameters (serum biochemistry and hematology analysis).
Hematology analysis, including a complete blood count and five part differential, was performed on EDTA anticoagulated blood using the Coulter AcT5 diff (Beckman Coulter, Fullerton, California).
Results of the hematology analysis are reported in Table 1.
Hematology analysis was performed on a Sysmex XE 2100 (Sysmex Europe GmbH, Norderstedt, Germany).
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Peripheral blood was collected by cardiac puncture after euthanasia, and hematological analysis was performed using the ADVIA automated hematology system (Bayer, Tarrytown, NY, USA).
All participants attended a standardized examination protocol in Beijing Xuanwu Hospital, including medical history, physical examination, blood hematology and biochemistry analysis, rest electrocardiography, and abdominal ultrasonography.
Cell-cytotoxicity assay, hemolyticity, as well as post-injection histology, hematology, and inflammation analysis further demonstrate their non-cytotoxic character and indicate further in vivo application.
Further blood samples were drawn for blood gas analysis, hematology and routine clinical chemistry.
Screening included a medical history, physical examination, blood chemistry analysis, hematology, urinalysis, and electrocardiography.
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