Dose reductions were based on nadir hematologic counts or maximum non-hematologic toxicity from the preceding cycle.
Continuous variables that vary with age (respiratory rate, blood pressure, hematologic counts) were regrouped as normal or abnormal by using age-specific normal ranges (4, 5 ).
It combines measures of physiologic dysfunction in six components: cardiovascular (heart rate × right atrial pressure/mean arterial pressure), respiratory (arterial partial pressure of oxygen/fraction of inspired oxygen [PaO2/FiO2]), renal (serum creatinine), central nervous system (Glasgow Coma Scale score), hepatic (serum bilirubin), and hematologic (platelet count).
After admission, the patients with major trauma were monitored in the following aspects: respiratory (partial pressure of arterial oxygen/fraction of inspired oxygen ratio), renal (serum creatinine concentration), hepatic (serum bilirubin concentration), cardiovascular (pressure-adjusted heart rate) and hematologic (platelet count) systems.
Six variables were obtained from the trauma data registry including a) the respiratory system (PO2/FIO2 ratio); b) the renal system (serum creatinine concentration); c) the hepatic system (serum bilirubin concentration); d) the hematologic system (platelet count); e) the central nervous system (Glasgow Coma Scale) and f) the cardiovascular system (PAR).
Hematologic dysfunction: platelet count <80,000/mm3 or to have decreased by 50% in the 3 days preceding enrollment.
The following measures of nonpulmonary organ failures were also abstracted: serum creatinine (kidney), serum bilirubin (liver), platelet count (hematologic variable), Glasgow Coma Scale score (neurologic variable), and (arterial hypotension or the use of vasopressors (cardiovascular variable).
12 At presentation, venous blood samples were obtained for parasite count, hematologic tests, and biochemical tests; three blood spots were collected on 3MM filter paper (Whatman, Maidstone, United Kingdom) for genotyping by polymerase chain reaction (PCR) in the event of reappearance of P. falciparum during follow-up.
Inclusion criteria were as follows: infection known or suspected on the basis of clinical data at study entry, two or more signs of systemic inflammation with the presence of sepsis-induced organ dysfunction, hematologic dysfunction (platelet count <80,000/mm), and the need for mechanical ventilation to stabilize the patient's general condition.
Inclusion criteria were a known or suspected infection on the basis of clinical data at study entry, two or more signs of systemic inflammation with at least the presence of sepsis-induced organ dysfunction, hematologic dysfunction (platelet count <80,000/mm) and the necessity of mechanical ventilation to stabilize the patient's general condition.
