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CD4 is an important accessory and costimulatory molecule that augments the signal received by the TCR complex and helps in the activation of the T cells 45. Blockade of this interaction using anti-CD4 antibodies increases the threshold of activation through the TCR, so that, under these conditions, only cells with high affinity have the capacity to be activated and proliferate 46.
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Both described mechanisms might help in the activation of the Pepc promoter in maize, particularly as transcription is not activated from the minimum level, but from an intermediate state.
In autoimmune diseases, B-lymphocytes are thought to play a pathogenic role as antigen-presenting cells and may provide help in the activation of T-lymphocytes that are the mediators of autoimmune destruction (6).
As an example, it has been shown that the activation of Chk2 helps in the elimination of potentially malignant cells [18], [19], and that familial loss-of-function mutations [20] or an acquired interruption of Chk2 activation [18], [19] contribute to oncogenesis.
EGCG has been found to have a number of cancer-protective actions in the body, including an ability to help in the de-activation of cancer-causing chemicals (carcinogens).
One of the critical function of SA involves the activation of SOD that helps in the deactivation of lipid peroxidation thus facilitates in maintaining the integrity of membrane structures of root cells (Zenkov et al. 2001; Belkadhi et al. 2013).
During the activation step, a redox reaction helps in the deposition of Ag layer on the sensitized frustules.
In all the prokaryotic GGTs, this threonine along with two neighboring residues is conserved as "TTH", where the second threonine and the following histidine have been reported to help in activation of the first threonine as a nucleophile in the GGT catalytic mechanism [ 17, 29– 31].
This protein plays a key role in the activation of macrophages and helps the cells survive under oxidative stress [39].
It has also been shown that 14-3-3ζ 14-3-3ζ 14-3-3ζo 'writers' and 'erasers' of histone modification, such as histone acetyltransferase (HAT) and histone deacetylases (HDAC) and helproteinsiating transcriptional activation of specific subind of mammalian genes and DNA replicatoon mediated through acetylation on Lys9 and Lys14.
Some help to silence genes, whereas others are involved in the activation of genes.
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