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The low-frequency (slow) modes containing a certain degree of anharmonicity (Gō et al. 1983) not only are able to describe functional, configurational changes (Brooks and Karplus, 1985) but also help in the refinement of X-ray structures (Kidera and Gō 1992a, b).
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Possible areas where validated in vitro based toxicogenomics test methods might play a future role include a) preliminary assessments (prescreens), b) complementary testing that might assist in obtaining additional (e.g., mechanistic) information, and c) surrogate tests that could help in the refinement, reduction, and replacement of animals used for omics-based or traditional testing methods.
They help our architects, project managers and developers in the refinement of architectural guidelines and communicate requirements to our integration partners and software suppliers.
Multicollinearity problems are more likely in the refinement of large structures; to some extent more precise and accurate algorithms can help.
Terrorism, in this age of Islamist extremism, has reached new peaks in the refinement of horror.
Similar protocols were applied in the refinement of all structures.
The authors wish to thank Dr. Diana Abdueva, Dr. Dmitriy Skvortsov and Dr. Shuzhao Li for providing the source code and data for the two alternate models examined in this study, and Dr. Jennifer W. Weller for review and help in refinement of the manuscript.
This document thus provides an initial set of sites that can be used by industry to help in the development or refinement of Listeria PEM programs.
| Christie's revels in the refinements of twentieth-century design in two sales on Sept. 26.
It was designed to assess whether mammographic density may help in refinement of breast cancer risk estimation using either the Gail model (Breast Cancer Risk Assessment Tool) or the Tyrer-Cuzick model (International Breast Intervention Study model).
Visual inspection of the alignments using the program MEGA1.4 [ 63] helped in refinement of the final alignments.
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