Due to an increase in consumerism, heightened dependence on technology, and an overall world population growth, more and more minerals and metals need to be extracted from the earth's surface as shown in Figure 1.
Several lines of evidence suggest that cancer cells have a heightened dependence on mechanisms of protein homeostasis (proteostasis) [ 2], including the UPS.
The proteotoxic crisis hypothesis suggests the attractive prospect that it may be possible to attack a broad range of human cancers by taking advantage of their presumed heightened dependence on PQC pathways.
Given that tumours may be hyperdependent on nutrient supplies and may scavenge extracellular protein to ensure sufficient amino acid availability, the VCP inhibitor-associated heightened dependence on amino acid supplies may be clinically relevant.
Cancer cells may have a heightened dependence on protein degradation pathways, as their numerous genomic mutations often effect an imbalance in protein levels or the production of defective proteins.
These include the loss of market share to foreign automakers, a potential peak in sales of large trucks and SUVs, "relatively modest capacity reductions due to rigid union agreements," unsustainable growth of the companies' obligations in healthcare and pensions, "a seemingly ever-heightening dependence upon incentives to move product," and the deterioration of credit quality.
Modern electronic media, with their instant "analyses" and search for simple, vivid narratives, heighten this dependence and the resulting anger when public/personal problems aren't immediately fixed.
The project only heightened Redding's dependence on Dr. Moon and the California Heart Institute.
This heightens Western Europe's dependence upon petroleum far beyond what had once been foreseen for this period.
From its relatively novel perspective, our study confirmed and extended several findings using other approaches, suggesting that male gender, stressful life events, dysfunctional family structure, anxious personality, and impulsivity are associated with a heightened risk for drug dependence (32).
Because of their low penetrance and inability to explain more than a small fraction of observed heritability, individual SNPs identified in GWASs are generally regarded as lacking sufficient sensitivity, specificity and predictive value to serve as clinical markers of heightened risk of nicotine dependence and persistent smoking in the general population [ 9].
