Integrating NIMART into existing PHC services heightened target-related performance pressures, which in some facilities created an increasingly unpleasant working environment.
Tumors overexpressing Skp2, e.g., because of dysregulated Emi1 over-inhibiting the APC/C, tend to have defective regulation of the G1/S or G2/M transitions due to heightened targeting of p27 by SCFSkp2 [ 78] (Fig. 5).
The risks of failing to achieve the target are heightened by the fact that the budget contained £8bn of tax cuts but only £5bn of tax rises.
The succinate that accumulates when SDH complex activity is impaired leads to reduced turnover of hypoxia-induced factor 1 alpha (HIF1Α) and heightened expression of HIF1A target genes including vascular endothelial growth factor [ 21].
"Backdoors expose all users of a backdoored system, not just intelligence agency targets, to heightened risk of data compromise".
It was unclear whether anyone was killed or wounded in these attacks, but the constituency of armed strikes and the bold choice of targets has heightened the profile of Syria's armed insurgency.
Similar to repeat victimisation, this heightened risk to neighbouring targets decays over time (Bowers et al. 2004).
The resulting interspecific recombination either breaks down genomic islands of heightened genetic differentiation surrounding the target loci of disruptive natural selection or entire chromosomal segments, including intact genomic islands, pass between species' genomes, homogenizing allele frequencies.
Besides a heightened sense of being surveilled, targeted and reviled coming off the recent elections and the rise of white supremacist visibility, misogyny and hate crimes, I was aware of the context I was going in and already gearing myself up for the situation.
Thus, heightened lysis of tumor cell targets at days 4 and 6 accurately reflects the net T cell cytolytic activity present, a product of T cell cytolytic capacity and T cell numbers, and is not spuriously affected by decreasing tumor sizes.
