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The I.A.T., it seemed, was picking up a heightened signal of suicidal tendencies that the most commonly used method for assessing risk — a clinical interview — had been powerless to detect.
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Furthermore, heightened anticipatory signals in the VS and anterior cingulate during reward trials may contribute to enhanced signal in the putative FEF, which in turn could exert an even greater top-down influence on saccade-related neurons in caudate and superior colliculus (Ding and Hikosaka 2006; Hikosaka et al. 2006).
These intriguing results indicate that pharmacological suppression of heightened mTOR signaling in Tuberous Sclerosis patients might be of therapeutic value.
Therefore, heightened mTOR signaling in TSC patients could feasibly be attenuated therapeutically through the action of metformin on AMPK and RAPTOR.
However, it was clear that there was heightened FGFR signalling indicated by increased FRS2 phosphorylation in the sensitive cells.
Although the mechanism underlying the activity pattern observed in adolescent VS cannot be directly determined from this study, heightened DA signaling is a potential contributing factor.
While targeted therapies for luminal B breast cancers have not yet become clinically apparent, the authors' initial findings point towards heightened PI3K signaling as a possible key contributor to aberrant proliferation and tumorigenesis.
Presumably, this theory also incorrectly predicts heightened BOLD signals for more variable arrays, where the need to inhibit an impulsive response driven by a single outlying element would be greatest.
Hallucinogens heighten sensory signals, but this is often accompanied by loss of control over what is experienced.
Most interventions that aim to help patients shift out of the state of tonic immobility involve the use of bottom-up somatic strategies coupled with mindfulness to heighten somatosensory signals.
Indeed, because SR cross-talk with growth factor signaling pathways is extensive and tumors tend to progress towards endocrine resistance under the influence of heightened growth factor signaling, combination therapies targeting both ER and ERBB receptors enhance progression free survival [ 89, 90].
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