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The phenomenon of 'genetic anticipation' is a hallmark of the (CTG n CAG n TNR instability disorders, in which an increase in the number of microsatellite repeats is correlated with an earlier age of onset and heightened severity of the disease in successive generations.
A GM decrease in this region may be linked to inhibitory dysfunction and hence a heightened severity of migraine versus TTH.
Our results, however, clearly show induction of chronic disease with heightened severity in the absence of IL-6.
Evidence is now well-established and particularly strong for reduced lung function, heightened severity of symptoms in individuals with asthmatics, COPD and ischaemic heart disease which includes heart attacks.
5, 7 However, previous estimates were derived primarily from areas with endemic cholera, and the heightened severity observed in this study is likely explained, at least in part, by participants' lack of pre-existing immunity to toxigenic V. cholerae.
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22 Alternatively, host-level protective effects of iron and folic acid deficiencies against Plasmodia may indicate that micronutrient supplementation could increase incidence of clinical malaria within an endemic population 23– 26 and heighten severity of disease episodes.
While these data are supportive of the dose-response hypothesis, the molecular underpinnings of this heightened disease severity on myocyte function remain largely unanswered.
This heightened disease severity was not due to an inability to control viral replication as there was no difference in the viral titer in the heart at the peak of infection.
Hospitalizations involving inter-hospital transfer deserve further investigation given this finding which corroborates prior reports which have described an association between interhospital transfer and both heightened illness severity and elevated hospital resource use [ 12- 14].
However, the odd angle of the challenge, the speed of the tackle and the clumsy nature of it all caused Davis to twist and fall awkwardly, heightening the severity of the contact.
And when she closes her eyes at night, she's living in gray-blue Manhattan as Marty, a literary agent with her hair pulled back to heighten the severity of her loveless life in the big city.
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