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Other findings in people affected by Parkinson disease include mitochondrial dysfunction, leading to increased production of free radicals that cause significant damage to brain cells, and heightened sensitivity of the immune system and neurons to molecules called cytokines, which stimulate inflammation.
Here, we provide a concise overview of the role of Nrf2 in protection against drug and chemical toxicity, with a focus on the numerous in vivo studies that have shown heightened sensitivity of Nrf2 null (knockout) transgenic mice to such insults.
Ventilation perfusion mismatch [ 12, 37], impaired diffusion of metabolic gases [ 38], respiratory muscle weakness [ 39], and heightened sensitivity of peripheral receptors [ 40, 41] have all been postulated as possible causes.
Yet, they encounter major challenges such as commercialisation of the university's and medical school's central purpose, perceived lack of accountability of higher education and heightened sensitivity of taxpayers towards ineffective and inefficient leadership in academia.
And something besides particle counts may be feeding the misery, experts say -- the heightened sensitivity of allergy sufferers.
Seeing Michele Asselin's portraits, I remember the heightened sensitivity of my first months as a parent.
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This, rather, seems to reflect heightened sensitivity to issues of race in the age of Obama, and the intrusive power of history.
It is concluded that we may anticipate heightened sensitivity to cultural perturbation of mire ecosystems during times of climate change, and thus that particular care in our approach to management of blanket peat landscapes is indicated at the present time.
Investors were also sifting through the latest batch of corporate report cards from companies that have heightened sensitivity to the plight of U.S. consumers.
Thus, C57BL/6 or BALB/c mice that consumed 20percentt ethanol in water for up to 6 months showed a greater frequency of activated T cells, increased rapid IFN-γ response, and heightened sensitivity to low levels of TCR stimulation, with no requirement for a second signal (Song et al. 2002; Zhang and Meadows 2005).
The well-publicised G4S Olympics security fiasco has heightened sensitivity to the risks of outsourcing.
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