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The present data showing increased levels of both M1- and M2-like muscarinic receptor binding sites and heightened responsiveness to oxotremorine further suggest a role for muscarinic cholinergic neurotransmission in some behavioral impairment reported in this animal model, and add support to the functional relevance of cholinergic neurotransmission in schizophrenia.
This heightened responsiveness allows the liquid metal to be deformed at rates exceeding 120 mm/s, greater than an order of magnitude faster than existing techniques for electrical deformation.
Using detection or discrimination measures or stimuli reported to trigger migraine (striped patterns or flickering lights) one finds differences between people with and without migraine, which is attributed to abnormal cortical processing in migraine, described by hyper- or hypoexcitability, heightened responsiveness, a lack of habituation and/or a lack of intra-cortical inhibition [50], [51].
This heightened responsiveness to the endogenous ER ligand perhaps also supports a role for ERβ subtypes in the generation of the estrogenic response.
Since two of four cell lines exhibiting heightened responsiveness to CD95-mediated signals following fractionated irradiation express mutant p53 and displayed little or no up-regulation of CD95, enhanced responsiveness did not correlate with p53 status and CD95 up-regulation.
MDD patients are believed to express a heightened responsiveness to negative emotional stimuli and a reduced detection of positive affect [ 66, 67], which is explained by hyperactivity of the affective neurocircuitry, including the amygdala [ 68].
Similar(47)
IFNα generated in response to self-RNA antigen is part of a positive feedback loop involving pDCs that supports increased TLR7 expression, thereby heightening responsiveness to self-RNA-containing immune complexes (Ganguly et al., 2009).
These data suggest that asthmatics with GER have heightened vagal responsiveness.
CONCLUSION: This is the first study to demonstrate that heightened platelet responsiveness to collagen and thrombin may be a risk factor for myonecrosis in patients undergoing elective PCI.
The achieved effect was a cultivation of collective AIDS awareness that heightened the responsiveness levels of HIV positives and their families and friends, medical professionals, government officials and charitable donors.
They have also been interpreted as indicators of a generally heightened immune responsiveness, itself a risk factor for auto-immune disease [19].
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