Not surprisingly, DDR defects are associated with genomic instability and tumor development, and hereditary mutations leading to DDR impairment cause heightened cancer predisposition as well as various other age-related pathologies [reviewed in (1, 2)].
A predisposition to stress is heightened when pigs are raised in unstimulating environments, Dr. Grandin said.
17 Severe, persistent pain may also lead to unwanted physiological responses, namely, increased adrenergic tone, augmented oxygen consumption, predisposition to hypercoagulability, decreased immune function and heightened risk of delirium.
In addition to PM being a surrogate for allergen exposure or being linked to a heightened response to allergen exposure, those with atopy may have an inherent predisposition to a heightened response to PM itself.
The heightened risk was observed after adjustment for other possible contributory factors, including genetic predisposition, which remains the most important influence.
Because I am also a successful, capable person with, I think, heightened levels of empathy that come from my own struggles, accepting that I have a predisposition to being anxious has helped me get better.
They may also be at heightened risk because of carriage of a known deleterious mutation in a highly penetrant breast cancer predisposition gene such as BRCA1 or BRCA2, or other mutations in rarer susceptibility alleles in genes including TP53, PTEN and the recently described lower penetrance 1100delC mutation in the cell cycle checkpoint kinase gene (CHEK 2) [ 3- 6].
Your emotions are surely heightened.
The Americans heightened the pressure.
They had acquired heightened attention.
Instead, he heightened his attacks.
