Sentence examples for heightened pain perception from inspiring English sources

Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased experimental pain sensitivity in rodents.We report that the proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) downregulates COMT mRNA and protein in astrocytes.

We have extended the analysis to examine formalin-induced inflammatory pain and the heightened pain perception to thermal and mechanical stimuli as a result of CFA-induced inflammation.

A recent systematic review of the literature by Fishbain, et al [ 60] found good evidence to suggest that these signs are associated with heightened pain perception.

Indeed, women are known to experience heightened pain perception and sensitivity and to have lower levels of opioid analgesia compared to men [ 39].

In animal models of HNSCC we showed that ATP in the cancer microenvironment likely heightens pain perception through the P2X2/3 trimeric receptors.

Pain catastrophizing is linked to heightened pain and poorer coping among individuals with chronic pain, yet little is known about how pain catastrophizing associates with sleep and pain over the course of treatment for chronic pain.

Soon, isolated mice showed sign of heightened pain sensitivity, suggesting that smell was likely the messenger.

It is thought that this heightened pain sensitivity results from both central as well as peripheral sensitization [41, 65].

Heightened pain catastrophizing also contributes to pain at presentation, pain-related disability, psychological distress, and postoperative outcomes [ 19- 22].

This could be redness, heightened pain levels, or an oozing of pus and/or fever.

Although sleep deprivation is known to heighten pain sensitivity, the mechanisms by which sleep modifies nociception are largely unknown.