This concern has been heightened since the occurrence of Wegeners Granulomatosis (an autoimmune vasculitis affecting the lungs and kidneys) in a subject who received a recombinant hepatitis B vaccine adjuvanted with ISS, an oligonucleotide similar to CPG 7909 [21].
This concern has been heightened by the occurrence of vCJD apparently related to blood transfusion [ 11].
In the late 1990s, such concerns were heightened by the occurrence of CJD among three patients 30 years of age who were deer hunters or ate deer and elk meat harvested by family members (Table 2).
However, the use of tolcapone is only limited to fluctuating patients who are refractory to other therapies, and requires heightened monitoring for the occurrence of hepatotoxicity.
This kind of disaster risks is expected to increase in the future due to climate change, whose impacts are likely to heighten the severity and occurrence of extreme HM events, such as droughts and floods (Stern 2007, p. 76; IPCC 2007, 2012).
These results underscore the need to heighten healthcare provider awareness of the occurrence of pertussis in adults, including older adults.
Factors such as increasing international travel, the globalization of food supplies and commerce and the occurrence of multinational epidemics including the 2009 Influenza A pandemic have heightened awareness of global health issues.
Tensions around the handover of power, already heightened because of the partisan nature of the recall, were expected to be worse than usual because of the rare occurrence in California of a governor being forced from power by the electorate.
"Dianetics" also promises heightened powers of intelligence and perception.
