Five of the remaining 23 treated patients had to be discarded because of unstable doses or persistently heightened TSH levels.
As was anticipated by the reviewer, we observed that priming with Drd1 receptor agonist SKF 81297 translated into a heightened response to a second dose of the agonist 48 hr later.
There appears to be a heightened risk of antibody formation with increased doses and frequency of administration.
Typical management of the more serious side effects includes heightened monitoring, delay in administration of next dose or suspension of magnesium sulfate therapy.
A recent case report [ 9] indicated heightened meropenem CL (20.8 L/h) and Vd (0.56 L/kg) during ECMO and RRT and a high-dose meropenem infusion was utilised to maintain optimal concentrations.
Of relevance to the low doses used in homeopathic treatment, the small size and heightened reactivity of nanoparticles [ 60] that increase bioactivity and bioavailability of drugs, antioxidants, and herbs [ 62, 63, 68] would downshift the hormetic dose response range even lower [ 39].
While these data are supportive of the dose-response hypothesis, the molecular underpinnings of this heightened disease severity on myocyte function remain largely unanswered.
Such individuals could be at heightened risk for developing calcium oxalate deposits were they to receive clinical doses of DCA over long periods of time.
By prescribing a full dose of Wit, a student body's involvement is heightened.
These studies indicate that increasing plasma doses could heighten the proportion of cells which are forced to undergo apoptosis, leading consequently to a progressive negation of positive effects.
