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This issue was recently addressed by Kurosaki and colleagues who convincingly demonstrated that the pre-antigen experience-induced repression of the Bach2 transcription factor contributes to the heightened differentiation activity of IgG1 memory B cells.
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The resulting interspecific recombination either breaks down genomic islands of heightened genetic differentiation surrounding the target loci of disruptive natural selection or entire chromosomal segments, including intact genomic islands, pass between species' genomes, homogenizing allele frequencies.
Thus Tcf3 deletion confers heightened resistance to differentiation in serum but does not substitute fully for LIF.
As predicted, the heightened Th2 cell differentiation in vitro in the absence of Cbl-b was abrogated by introducing Stat6 deficiency.
Recurrent reproductive cycles elicit transient but significant alveolar epithelial expansion, whereas pregnancy involves heightened lobuloalveologenesis and lactational differentiation.
We reasoned that heightened oxidative defenses upon differentiation may render decidual cells largely unresponsive to environmental ROS, thus accounting for the restricted activation of MAPK pathways in response to H2O2.
The expression of IL-4Rα was comparable between WT and Cblb−/− CD4+ T cells (data not shown), suggesting that the heightened Th2 and Th9 cell differentiation in Cblb−/− T cells does not result from increased IL-4Rα expression.
These cellular functions, which include heightened resistance of muscle progenitor cells to apoptosis, migration to site of injury, and prevention of premature differentiation are highly desirable in the healing cascade after acute muscle trauma.
After three exposures, proliferation became confined to localized buds in the basal layer and increased terminal differentiation was observed (compact hyperkeratosis of the stratum corneum, elevated levels of K10 and filaggrin, and heightened transglutaminase activity).
In an era of expanding postsecondary markets and heightened student and institutional competition, students' field of study decisions may be becoming an increasingly important point of differentiation in the process of social mobility.
Your emotions are surely heightened.
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