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Perhaps the depth and duration of proteasome suppression achieved in vivo is sufficient to kill MM plasma cells teetering on the edge of UPR-dependent apoptosis, but not strong and long enough to kill MM stem cells and most solid tumor cells, including those that may have a heightened dependency on the UPS.
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The Chinese government has always been wary of that dependency, but its fears were heightened in recent weeks after the United States banned American companies from selling components to ZTE, a prominent Chinese telecom equipment manufacturer.
However, its danger lies in its discretion: Take it for more than five consecutive days, and you could develop a dependency, and withdrawal from valium can give you an array of contradictory symptoms, like heightened anxiety and irritability.
The 80th centile of midwifery staff available and patient dependency scores for each shift by weekdays are presented in figure 2. There was heightened clinical activity midweek throughout the year.
Ofgem said tough emissions targets, the UK's increasing dependency on gas imports, and the closure of ageing power stations were contributing to the heightened risk of shortages.
The global financial crisis, tough emissions targets, the UK's increasing dependency on gas imports, and the closure of ageing power stations were all contributing to the heightened risk of shortages, Ofgem said.
Heightened emotions.
Your emotions are surely heightened.
The Americans heightened the pressure.
They had acquired heightened attention.
Watercolor heightened with gouache.
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