Sentence examples for heightened dependence from inspiring English sources
Several lines of evidence suggest that cancer cells have a heightened dependence on mechanisms of protein homeostasis (proteostasis) [ 2], including the UPS.
The proteotoxic crisis hypothesis suggests the attractive prospect that it may be possible to attack a broad range of human cancers by taking advantage of their presumed heightened dependence on PQC pathways.
Given that tumours may be hyperdependent on nutrient supplies and may scavenge extracellular protein to ensure sufficient amino acid availability, the VCP inhibitor-associated heightened dependence on amino acid supplies may be clinically relevant.
Cancer cells may have a heightened dependence on protein degradation pathways, as their numerous genomic mutations often effect an imbalance in protein levels or the production of defective proteins.
In theory, this creates in cancer cells a heightened dependence on protein quality-control (PQC) mechanisms, including protein chaperones, the UPS, and autophagy [ 9- 12].
Modern electronic media, with their instant "analyses" and search for simple, vivid narratives, heighten this dependence and the resulting anger when public/personal problems aren't immediately fixed.
The project only heightened Redding's dependence on Dr. Moon and the California Heart Institute.
From its relatively novel perspective, our study confirmed and extended several findings using other approaches, suggesting that male gender, stressful life events, dysfunctional family structure, anxious personality, and impulsivity are associated with a heightened risk for drug dependence (32).
Because of their low penetrance and inability to explain more than a small fraction of observed heritability, individual SNPs identified in GWASs are generally regarded as lacking sufficient sensitivity, specificity and predictive value to serve as clinical markers of heightened risk of nicotine dependence and persistent smoking in the general population [ 9].
This dependence has been heightened by a decline in the ecological health of the Temba homeland because of overpopulation, overgrazing, and soil erosion.
Chances of moving from use to abuse and dependence are therefore heightened, especially considering other factors such as age of onset and frequency of use.
