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This may readily explain the heightened body weight in Mecp2 knock-out mice (Fig. 1B).
In our investigations, we nevertheless observed compelling evidence not only for heightened body weight, but also for alterations in feeding behaviour since Mecp2 Stop mice spent more time in zones associated with the food hopper and they also ingested more chow than WT controls.
Aged 8 9 months, Mecp2 Stop mice presented with heightened body weight, lower overall activity in the open field, but no anxiety phenotype.
Throughout this period, Mecp2 Stop mice presented with heightened body weight compared to WT (Fig. 1B; F 1,432) = 75.38; p < 0.0001) mimicking a phenotype observed in Rett patients [27].
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Heightened body awareness can be adaptive and maladaptive.
Together, we see a deleterious environmental effect of being reared by previously neglectful mothers that manifests itself in terms of lower adult body weight, heightened flipping, decreased dam weight, and decreased number of maternal defense attacks (Fig. 4).
Both of the aforementioned issues could be of particular concern postpartum when many women have heightened awareness of their body weight and are busy with a new baby.
Birds fed the HAA diet had greater body weight by d 35 and heightened Lactobacillus content in the ileum at d 16 (P < 0.05).
However and important for the interpretation of experimental data, commercially available strain-, age- and gender-matched animals that were shipped over-night showed elevated glucocorticoid levels for up to three weeks after shipment, indicating a heightened HPA axis activation and they gained less body weight during adolescence.
The global obesity epidemic has heightened the need for an improved understanding of how body weight is controlled, and research using mouse models is critical to this effort.
In addition, this had heightened applicability for assessing the influence of alterations in fluid status on body weight, a common phenomenon in the critical care setting (Plank et al, 1998).
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