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Heightened activation of the NMDA receptor may cause poor sleep architecture, while augmentation of the GABA receptor may improve sleep architecture.
This preliminary work suggests that intravenously injected VP2 peptide has access to the CNS through low levels of BBB permeability potentially resulting in heightened activation of CNS infiltrating CD8 T cells in this model.
During cardiac hypertrophy and/or heart failure processes, there is sustained heightened activation of the sympathetic nervous system [ 19].
Relative to controls, IBS participants showed heightened activation of the ACC, IC, and ventral medial prefrontal regions, suggesting heightened affective responses to painful visceral stimuli [ 38].
The decreased angle corresponding to the cessation of myoelectric silence during fatigue observed in our study might reflect heightened activation of the deep muscles compensating for superficial lumbar ES fatigue.
Noteworthy, also in human CHF, chronic heightened activation of the sympathetic system and associated enhancement of catecholamine-induced signaling pathways have adverse prognostic significance and may accelerate the pathological processes (Esler et al. 1997).
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Taken together, these results suggest that, although there are increased numbers of Ly6Chigh and Ly6Clow splenic CD11b+F4/8 0+cells in CreLysM Casp8fl/fl mice, these cells do not promote heightened activation and functionality of surrounding cells and in fact are capable of suppressing CD4+ T-cell proliferation on a per-cell basis.
The researchers found that women experiencing stereotype threat while taking a math test showed heightened activation in the ventral stream of the anterior cingulate cortex (ACC), a neural region thought to be associated with social and emotional processing.
The finding of high CD38 levels positively correlated with Leishmania infection reinforces the idea that leishmaniasis can be a cofactor to of this heightened activation status.
No frontal lobe areas showed heightened activation during late blocks relative to early blocks when applying a liberal uncorrected threshold of P<0.01.
The Emory University neuroscientist Gregory Berns found that people who dissent from group wisdom show heightened activation in the amygdala, a small organ in the brain associated with the sting of social rejection.
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