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Infection with Escherichia coli (E. coli) often provokes severe inflammation, greatly reduces milk yield and may eventually cause heavy tissue damage in the mammary gland [ 1, 2].
Mastitis caused by Escherichia coli is typically self-limiting and of short duration, but can be associated with severe clinical signs, reductions in milk yield and heavy tissue damage to mammary gland [ 3- 5].
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The disease typically commences with the development of fatty liver (i.e., hepatic steatosis); with continued heavy alcohol consumption, steatosis may transition to inflammation, resulting in tissue damage and fibrosis (see figure 1).
To separate damage responsive genes from osmotic response genes, we compared the ORG list to genes regulated by the heavy metal cadmium, which has been used previously as a control for the transcriptional effects of tissue damage [8], [12].
Heavy metals become toxic when they are not metabolized, which allows them to accumulate in several organs leading to tissue damage due to their toxicity [ 79, 80].
Severe tissue damage can occur.
There's no tissue damage, no trauma, no infection.
The serum, or antivenin, reduces swelling and tissue damage.
Death was accompanied by widespread tissue damage.
Tissue damage, in the forms of bronchitis and emphysema, is evident when the cross section of a normal lung is compared with the lungs of light and heavy smokers.
Increased NET-mediated tissue damage in dectin-1-deficient mice.
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