Sentence examples for heavy mutation from inspiring English sources
These heavy mutation loads affect overall plant fitness based on evaluation of agronomic traits (Table S3).
Bacteria such as the radiation-resistant Deinococcus radiodurans apparently survive heavy mutation rates not by lateral gene transfer but by accumulating multiple copies of genes, and this is all that I am proposing.
As chromosome one and four have the lowest level of CNVs across the nine CHO cell lines, some of which have encountered heavy mutation pressure over a long period of time [ 10], these chromosomes may be considered attractive landing platforms for knock-ins of heterologous genes.
The counterbalance of this would be, however, that this larger and older group would probably also carry a heavier mutation load than the speciating group.
Whilst this would not be a problem for the younger group, it would most probably result in a very significant drop in fertility for the older and more numerous ancestral stock because it would carry a heavier mutation load.
The presence of a myosin heavy chain mutation causing hypertrophic cardiomyopathy can be predicted from a simple functional assay.
One myectomy myosin sample produced a consistently higher sliding speed than donor heart myosin and was identified with a disease-causing heavy chain mutation (V606M).
Alternatively, use of the same CD47 antibody with a D265A Heavy Chain mutation to eliminate FcR binding would be a useful contriol.
However, Schmitt et al. showed that pressure overload induced by trans-aortic banding did not profoundly exacerbate cardiac hypertrophy in an HCM mouse model with a myosin heavy chain mutation.
Interestingly, in the wing there is a strong genetic interaction of ck/MyoVIIA with the fz-dsh-Drok-sqh-zip pathway, where ck/MyoVIIA mutations have the opposite effect of zip/MyoII heavy chain mutations [26] (Fig. 5A).
By this mechanism, dynein heavy chain mutations may result in normalizing kinesin-2-mediated transport of ChAT inhibited by the misfolded SOD1 species.
