The observed higher incidence in our study could be attributed to the heavily administered prior therapies or the addition of everolimus.
These programmes are centrally administered, heavily controlled and focus on a few specific conditions (commonly linked to current donors' priorities, e.g. Malaria) to maximize likelihood of impact [ 15].
Bigger schemes makes raising capital a challenge, and in Scotland developers tend to be at two extremes: businesses and wealthy estate owners or impoverished small landowners and farmers borrowing heavily to try to administer the kiss of life to dying tracts of land.
PL-MLP has a long circulation time, was well tolerated, and can be administered to heavily pretreated patients at a single dose of 3.0 mg/kg and cumulative dose of 10 12 mg/kg before development of prolonged thrombocytopenia; this is nearly threefold the equivalent dose of MMC tolerated historically.
In fact, wary of corruption and hamstrung by local hostility, American officials say that as in Iraq they will rely heavily on private contractors to administer the development aid, a decision that could eat up as much as half the budget.
But it also became heavily used by doctors who administered it intravenously in outpatient clinics for periodic patient "tune-ups," as they were sometimes known.
A pilot version typically starts under favorable conditions, crafted to precise specifications and administered by people heavily invested in its success.
Patients receiving venovenous or venoarterial ECMO have traditionally been considered too unstable for active physical therapy, frequently are heavily sedated, and occasionally are administered neuromuscular blocking agents.
53, 54 In the first trial, oregovomab was administered to 13 heavily pretreated, recurrent ovarian cancer patients, including 6 women with platinum-resistant disease.
The introduction of the platinum compound oxaliplatin in the treatment of colorectal cancer has increased response rates up to 25% even in heavily pretreated relapsing patients when administered in combination with 5-FU (Bleiberg, 1996).
