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Achieving both biocompatibility and improved heating efficacy without compromising on either factor poses a huge challenge in the research of clinical magnetic hyperthermia.
Equation 4 may be viewed as NP heating efficacy depending on r0, Kabs, ρ0, c0, tP, and k∞ under action of radiation energy density E0.
Carbon nanotubes and ferrite compounds have been utilized as MW agents for MW thermotherapy [12 16], whose heating efficacy was too low to use in vivo.
Since iron oxide nanoparticles are injected into the biological system to bring about the temperature raise, a system with a very good biocompatibility and heating efficacy is the fundamental requirement for an efficient magnetic hyperthermia system.
Surface functionalization of Fe3O4 NPs with biocompatible HLC gave improved stability, heating efficacy, and reduced toxicity towards normal cells, thereby enhancing the potential of magnetic hyperthermia in cancer treatment.
Nonabsorbing layer of protein with different index of refraction in comparison with ambient bioliquid can lead to increasing of scattering efficiency factor of GNP and decreasing of heating efficacy and possibility to satisfy the optical confinement.
Similar(53)
Further work is currently underway to assess the RF-induced heating efficacies of AuNP3 in both in vitro and in vivo environments.
N: TOA net radiation change; F: effective radiative forcing; ΔT: transient temperature change; λ: (effective) climate feedback parameter; λ eq: equilibrium climate feedback parameter; κ: ocean heat uptake efficiency; ε: ocean heat uptake efficacy; ΔT eff: effective climate sensitivity (in the case of 2xCO2 forcing); ΔT eq: equilibrium temperature change.
The ocean heat uptake efficacy associates the temperature response induced by ocean heat uptake with equilibrium temperature response, and the efficacy of forcing compares the temperature response caused by non-CO2 forcing with that by CO2 forcing.
In this local feedback framework, an increase of ocean heat uptake efficacy is interpreted as the region of ocean heat uptake shifting to the region of the less positive local feedback parameter, such as that for subpolar oceans.
Here, Eq. (20) means that the ocean heat uptake efficacy parameter represents the ratio between feedbacks operating under radiative forcing and ocean heat uptake alone.
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