High fat diet intake promoted reactive oxygen species production and suppressed autophagy in the heart, the effects of which were attenuated by catalase.
Whereas pressure or volume overload seem to increase cardiomyocyte proliferation in the fetal mammalian heart, the effects of such hypertrophic stimuli on the relevant molecular pathways have not been identified (Saiki et al., 1997; Sedmera et al., 2003).
In the heart, the effects of neonatal toxicant exposure were less statistically robust than for the liver, but we nevertheless found differences between the two OPs [treatment × (DZN vs. PRT), p < 0.07], as well as treatment interactions with age and AC stimulant (treatment × age × AC stimulant, p < 0.04).
Thus, the proarrhythmic effect of estrogenic chemicals in female rodent hearts was dominated by the stimulatory ERβ rapid signaling, whereas in male hearts the effect of ERβ was present but masked by the inhibitory ERα signaling, resulting in a lack of observable response.
Better knowledge is needed of the late effects of modern systemic treatments and of radiotherapy to critical structures of the heart, including the effect of both radiation dose and volume of the heart exposed.
Examination of this particular action of diidroquinidine on the isolated heart and the effect of some photodynamic substances (that is, hæmatoporphyrin) on the function of isolated hearts of mammals and amphibians2,3 suggested the opportunity of investigating the photodynamic effect of diidroquinidine on isolated mammal hearts by electrocardiographic technique.
The purpose of this study was to investigate the trabecular structure of the endocardial wall of the living human heart, and the effect of that structure on the measurement of myocardial function using MRI.
In assessing whether homocysteine causes ischaemic heart disease, the effect of lowering serum homocysteine in reducing cardiovascular disease risk in patients with homocystinuria is relevant.
One of the criteria used in this study to differentiate the third heart sound from splitting of the second heart sound was the effect of high heart rate on the third heart sound.
International Maritime Organization (IMO) guidance recommends implementing Human Error Assessment and Reduction Technique (HEART) for assessing the effect of human error probability considering quantitative risk analysis of shipping and offshore operations.
