Elevated left ventricular end-diastolic pressure in isolated rat hearts stimulated relaxin gene expression, providing a possible mechanism for the finding of enhanced relaxin expression in ventricles from heart failure patients.
A study in the chioralose urethane anesthetized beagle dog assessed the potency of darifenacin, tolterodine, oxybutynin, and propiverine on pelvic nerve-stimulated bladder contractions, trigeminal nerve stimulated salivation, and heart rate (Gupta et al 2006).
Perhaps starting at home with their parents, they've learned how to turn older people on, or at least touch their hearts, stimulate their protective instincts, and make them feel guilty.
These data suggest that these apelin peptides enhanced ATP formation in reperfused hearts, stimulating glucose utilization.
These data demonstrate that acute modulation of HBP and protein O-GlcNAcylation in the heart stimulates fatty acid oxidation, possibly by increasing plasma membrane levels of FAT/CD36, raising the intriguing possibility that the HBP and O-GlcNAc turnover represent a novel, glucose dependent mechanism for regulating cardiac metabolism.
Echocardiography revealed that the B1KO mice display significantly decreased ejection fraction compared to control wild type (WT) mice, both under normal conditions (sham groups) and at 4 weeks post-MI, as expected since the β1AR is the major βAR subtype in the heart stimulating contractility (Table 1) [ 8].
For example, the observation of heart rate irregularities in chicken embryos suggested that embryonic heart was stimulated by nervous system starting from day 12/13 [ 26].
"When a normal heart rate stimulated by electricity exceeds 250 times a minute, the entire conduction system breaks down and the heart goes into cardiac arrest".
In 1961, inspired by the way the muscles in the heart were stimulated, he was the first doctor to enable paraplegic patients to move their limbs by electronically triggering their muscles.
