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As the heart progresses rapidly from a compensated state to a state of decompensated failure, vascular growth cannot keep pace with myocyte growth.
The identification of molecular signals that cause or modify cardiomyopathies is necessary to understand how the normal heart progresses to cardiac hypertrophy and heart failure.
However, to understand how the normal heart progresses to cardiac hypertrophy and heart failure, the molecular signaling pathways and gene expression programs that together control the growth and differentiation of cardiomyocytes need to be studied in depth.
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Taken together, these studies make it reasonable to speculate that increased triglyceride content is a consequence of fatty acid overload to the heart, progressing more rapidly after saturation of the oxidative capacity.
Kyle will miss that fixture but is hopeful of being available for a play-off round should Hearts progress.
There was limited consolation for an out-classed Hungarian outfit late on when Daniel Bode headed home from close range, but Hearts progress to the play off stages in convincing style.
As heart failure progresses, the heart often enlarges and changes shape.
If heart block progresses into severe second-degree or third-degree stages, a pacemaker is implanted for proper function.
As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation.
According to the cytokine hypothesis by Seta et al., heart failure progresses because proinflammatory cytokines exaggerate hemodynamic abnormalities or because they directly induce cardiac cell death [ 53].
This study has revealed the importance of serially assessing pyruvate metabolism under in vivo conditions, at frequent time points as heart failure progresses.
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