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She had a rare heart malformation.
The baby was born minutes before with a severe heart malformation that would require complex surgery.
But when 6-year-old Katie Coolican died in 1983 from an undiagnosed heart malformation, it was her mother, Maggie, a nurse, who asked about donating the child's organs — "to make some sense of it all," Ms. Coolican, of East Hampton, Conn., said in an interview.
A major heart malformation was found in 13 (15%) cases.
However, her twin brother has just died of heart failure, and she has the same heart malformation.
Importantly, knocking down TPP1 led to multiple abnormalities in zebrafish embryogenesis, including neural death, heart malformation, and caudal defect.
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Alone, this may not be serious; in some heart malformations it is even necessary for life.
Symptoms may include short stature, webbed neck, kidney or heart malformations, underdeveloped sex characteristics, or sterility.
Guidelines state that potential donors should be assessed for conditions with a genetic component – cleft palate, spina bifida, congenital heart malformations, psychosis and others – but that decisions on eligibility should be individualised.
The cat cry, which typically diminishes with age, is accompanied, to varying degrees, by symptoms of intellectual disability, mild facial abnormalities, anomalies of dermal ridge patterns (fingerprints, palm prints, and footprints), heart malformations, a small head (microencephaly), an excessive space between the eyes (ocular hypertelorism), and a failure to thrive.
They may also help shed light on congenital heart malformations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com