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Close distribution of influenza virus antigens, up-regulated trypsins, inflammatory infiltrates in injured heart loci indicates a mutual close-relationship among these pathogenic factors.
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Next, we examined the size of intronic and intergenic regions of heart gene loci and noticed that, on average, GeneTs featured 3.0-fold shorter intronic regions than GenePs (Wilcoxon rank sum P = 2 × 10−26, Figure 2D).
Genetic mapping in the context of the transgenic sensitizer has yielded seven heart failure modifier (Hrtfm) loci that modify disease progression.
We dubbed enhancers separated from their target genes by at least one nonheart gene or exon as tele-enhancers, and the enhancers located within the loci of heart genes as proximal enhancers.
In another genome-wide study, however, the authors reported that the HNF1A locus was not associated with coronary heart disease (CHD), although the locus was associated with CRP levels [ 5].
Despite the warm feelings it now evokes in north European hearts, as a locus of healthy food and blissful ecology, the Mediterranean is a perilous place for sailors.
Ramirez, J. et al. Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy.
For example, the prediction performance for type 2 diabetes and coronary heart disease using known associated loci have area under the curve (AUC) ranging from 0.55 ~ 0.68 [ 8, 9].
America was now her country: the locus of her heart and hopes.
One study of British veterans found that over the course of the 20th century, post-traumatic disorders did not disappear, but rather changed form: the gut replaced the heart as the most common locus of weakness.
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