This study was designed to investigate the capability of a small-animal SPECT imager, FastSPECT II, for dynamic rat heart imaging and to characterize the in vivo kinetic properties of 99mTc-C2A-glutathione-s-transferase (GST), a molecular probe targeting apoptosis and necrosis, in detecting cell death in ischemic reperfused rat hearts.
Dynamic, volumetric "whole-organ" scanning significantly reduces image acquisition time; "single-beat whole-heart imaging" results in improved image quality and reduced radiation exposure and reduced contrast dose.
In a heart imaging study of dozens of pregnant women, Johns Hopkins researchers found that severe forms of the blood pressure disorder known as preeclampsia damages the heart's ability to relax between contractions, overworking the organ and making it poor at pumping blood.
Preliminary biodistribution studies in rats indicate poor heart-to-blood ratios (less than 1.0), suggesting that the complex is not a useful reagent for heart imaging.
Deep-learning systems for breast and heart imaging have already been developed commercially.
Figure 5 IG3 ex vivo heart imaging and uptake.
Wu et al., pioneered the reporter gene approach in the heart by imaging in vivo transplanted cells (expressing luciferase or HSV1-sr39tk) up to 2 weeks by F-FHBG PET imaging or BLI [ 78].
However, the robustness of the data as shown by right heart catheterization and imaging in all subjects following diagnosis of CTEPH and CTPVD suggests that this program could be a practical approach for diagnosis of CTEPH after acute PE.
Jenista, ER, Wendell, DC, Klem, I, Ibrahim, ESH, and Rehwald, WG. "Introduction to cardiovascular magnetic resonance imaging". In Heart Mechanics: Magnetic Resonance Imaging-Mathematical Modeling, Pulse Sequences, and Image Analysis, 121-177.
Although the current study is a major step forward in the direction of clinical use of MIBG imaging in heart failure patients, several limitations are important.
