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Metabolic changes in the heart have been implicated in the increased incidence of myocardial infarction [ 2], with diabetic patients having decreased cardiac glucose metabolism and increased cardiac fatty acid metabolism [ 3- 6].
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In addition, altered adrenergic innervation to the heart has been implicated in sudden cardiac death following myocardial infarction (Chen et al., 2001).
Both anxiety and elevated heart rate (HR) have been implicated in the development of hypertension.
Low-exponent values represent reduced fractal propertiy of heart rate dynamics and have been implicated in the risk of fatal cardiac arrhythmia, increased mortality, or poor prognosis in cardiovascular diseases [32], [33], [34], [35].
Low-exponent values represent reduced fractal properties of heart rate dynamics and have been implicated in increased risks of fatal cardiac arrhythmia, increased mortality, or poor prognosis in cardiovascular diseases [ 30- 33].
Figures at the heart of the Italian game have been implicated.
Heart failure and pulmonary edema have been implicated as causes for weaning failure in mechanically ventilated patients; however, the identification of these conditions could be challenging in critically ill patients.
Several genes have been implicated in heart tube formation, yet we know little about underlying cellular mechanisms.
ROS have also been associated with neurodegenerations such as Alzheimer's disease, heart disease and cancer, and they have been implicated in aging [9].
Recently, alterations of multiple metabolites have been implicated in heart failure; however, the lack of an effective technology platform to assess these metabolites has limited our understanding on how they contribute to this disease phenotype.
Over 500 kinases are predicted to be encoded by the human genome [ 23], 200 of which have been implicated in heart disease [ 24- 26], as reviewed previously [ 27, 28] (Table 2).
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