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These results corroborate the association of metabolic imbalance and obesity to increased risk for heart dysfunction.
Background: Right heart dysfunction is a major cause for early morbidity and mortality after heart transplantation.
Valvular heart dysfunction is a significant cause of morbidity and mortality around the world.
Finding novel approaches to prevent and attenuate heart dysfunction associated with advanced age is a major therapeutic challenge.
The nucleus is ultimately the final target for many therapeutics treating various disorders including cancers, heart dysfunction and brain disorders.
These findings suggested that SPRC might be a potential agent for the treatment of diabetic heart dysfunction.
The authors investigated perioperative levels of vasopressin in patients with isolated right-sided heart dysfunction from chronic thromboembolic pulmonary hypertension.
Patients with left-sided heart dysfunction and volume overload often have associated elevations in vasopressin from neuroendocrine activation.
The experiments presented here indicate that HFD and reduced PGC-1 expression levels have the ability to modify the offspring's metabolism leading to heart dysfunction.
Heart dysfunction phenotypes (partial conduction block, non-contractile cells in the heart, ostia defects) were analyzed using the chi-square test and one representative experiment is shown.
Birse, R. T. et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.
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