Sentence examples for heart development in zebrafish from inspiring English sources

To investigate further whether IP3R-mediated Ca2+ signaling is required for AV cushion development, we utilized a relatively simple model of heart development in zebrafish treated with an inhibitor of IP3R (Fig. 5A).

The close resemblance of the genetic cascade governing heart development in zebrafish to that of humans has propelled the zebrafish system as a cost-effective model to conduct various genetic and pharmacological screens on developing embryos and larvae.

Here, we show that Tie-1 and Tie-2 have redundant roles in heart development in zebrafish, and that loss of Tie-2 signaling protects zebrafish from atorvastatin- and simvastatin-induced bleeding.

In summary, our results show that Tie-1 and Tie-2 have redundant roles in heart development in zebrafish and more specifically in the maintenance of endocardial-myocardial interaction.

For example, Sp1 has consistently been found in searches for cardiac transcription factors and is associated with the regulation of many cardiac genes [ 37- 39], KLF4 is a critical transcriptional regulator of stress responses in cardiomyocytes [ 25- 27], Smad3 is a key mediator of cardiac inflammation and fibrosis [ 40], and ZNF143 is critical for heart development in zebrafish [ 41].

Here, we determined the role of the extracellular matrix protein Nephronectin (Npnt) in heart development using the zebrafish model system.

We designed Nkx2.5- and Nkx2.7-MO to study whether Nkx2.5 or Nkx2.7 is required for heart development of zebrafish.

Taken together, the decrease of heart defects across samples indicates that Nkx2.7 and Nkx2.5 function redundantly during the heart development of zebrafish embryos.

Baker et al 21 studied cardiac development in zebrafish and found that zebrafish heart development undergoes first, the process of cardiac jogging and second, asymmetry of cardiac looping.

Tehrani, Z. & Lin, S. Endocrine pancreas development in zebrafish.

Gerri, C. et al. Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish.