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Bodmer, R. Heart development in Drosophila and its relationship to vertebrate systems.
In this study, we explored the effects of caldesmon knockdown on vertebrate heart development in vivo.
In the present studies, we further investigate the role of N1 on heartbeating and heart development in axolotls.
Yet Morrison, Red-Horse and their colleagues did not set out to understand congenital heart disease or to change how people thought about heart development in utero.
These results raise the possibility that ADAMs 9, 17, and 19 contribute to heart development in humans and have implications for understanding the mechanisms underlying congenital heart disease.
We have also discovered that the N1 gene product is related to heart development in the Mexican axolotl [Cell Mol. Biol. Res. 41 (1995) 117].
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Aberrations in heart development result in congenital heart defects (CHDs), which affect 1 in 100 infants in the United States each year.
Canonical Wnt signaling has been demonstrated to play a biphasic role during in vivo heart development and in vitro cardiac differentiation in several species6,49,50.
Environmental chemicals, drugs, and maternal nutritional imbalances can interfere with regulatory pathways involved in heart development early in gestation.
Since extracellular matrix plays an essential role in heart development and maturation in vivo, we sought to develop a synthetic culture matrix that could enhance functional maturation of iPSC-CMs in vitro.
In addition, reduced blood vessel development in the embryo proper likely contributes to the smaller size and in combination with defective heart development results in lethality of the EC-DKO mutant embryos.
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