The Nr2f2-null mutant mice die during the early embryonic development due to defects in angiogenesis and heart development [22].
Insulin resistance is strongly associated with the development of heart failure due to cardiotoxicity induced by the hyperglycemic state with subsequent modification of contractile proteins [1] and development of cardiac dysfunction [2].
The consequent cardiac remodeling might eventually lead to functional decompensation and development of heart failure due to apoptosis of cardiac myofibroblasts (Camelliti et al., 2005).
Diagnosis of PPCM was based upon development of symptoms of heart failure due to systolic dysfunction in the last month of pregnancy or within five months after delivery without any identifiable cause of heart failure or recognizable heart disease prior to the last month of pregnancy.
Macroscopic mapping (over >1 cm2 areas) of transmembrane potentials and intracellular calcium in these cultured cardiomyocyte networks is a relatively new development and lags behind whole heart imaging due to technical challenges.
Loss of Nkx2-5 in mice leads to arrested heart morphogenesis due to blocked progenitor growth, defective chamber and conduction system development, and a deranged GRN (Prall et al., 2007).
Zebrafish are an excellent model to study the mechanisms of natural heart regeneration due to a wealth of accumulated knowledge about heart development and the availability of many molecular, genetic and genomic tools [11], [12], [13].
The animal had died of heart failure, due to overstrain.
Don'terio's cause of death was heart failure due to an undiagnosed heart ailment.
His death certificate says he died from "acute heart failure due to natural causes".
