Transcriptional-translational feedback loops lie at the very heart of the core clock mechanism.
Maret et al. similarly noted sleep induced changes in liver Cirbp expression[ 16], Thus we questioned if sleep and sleep deprivation specifically influence the expression of core clock genes in heart and lung.
Effectively, three other core clock genes appear as regulated in larvae (bmal2), hearts (clock3) and cells (cry3) only.
As shown in Fig. 5, the expression pattern of the core clock genes (Per2, Bmal1, and Clock) exhibited a 24 hr rhythmicity in the heart, skeletal muscle and fat of WT mice, consistent with previous observations [49], [50].
But in hearts removed from heart-specific clock mutant mice, that oscillation was completely lost.
In the heart, several clock genes responded to the light exposure.
Using a mouse model in which heart-specific clock cells were disrupted, Young found these cells directly regulated triglyceride metabolism, as reported 25 November 2009 ahead of print in the Journal of Biological Chemistry.
Ditto heart-shaped clocks, pretty candles, leopard-print picture frames and butterfly-covered diaries.
At the heart of the clock, which occupies two rooms, is a single ion of strontium — a pliable metal known for its ruby incandescence in fireworks, and number thirty-eight on the periodic table.
An eighteen-year-old athlete with a charmer's smile and no bad habits, heart like a clock, limbs of hammered wire, studious, dutiful, not a wild bone in his body?
