In accordance with several other groups, we found 177Lu-DOTATATE PRRT dosimetry based only on 2-D scanning problematic due to inherent difficulties of delineating healthy organ uptake from tumours and physiological uptake as in the bowel [12, 28, 29].
Within these volumes, the volume best suited for reduction of variability of healthy tissue uptake was selected by calculating the coefficients of variation of grey matter (GM) and white matter (WM) uptake in HC after normalisation to each eligible brain region.
Healthy Start vitamin uptake by mothers and babies, particularly in inner-city areas, has been extremely poor.
Due to the overexpression of folate receptors on target cells as opposed to healthy cells increased uptake of MTX conjugated nanoparticles in tumour cells was demonstrated.
The NHS Breast Screening Programme is an efficient setting for recruiting large numbers of healthy older women: uptake of breast screening in women aged 65 70 years is over 70% (NHS Breast Screening Programme, 2009).
We have shown that in healthy rats the uptake of C-labelled lipids was about tenfold higher in liver than in skeletal muscle [ 35].
In a healthy primate, brisk initial uptake (peak standardized uptake value (SUV) = 2.0 at 2.5 min) was observed throughout all brain regions, followed by rapid egress of the radiotracer from the brain.
For clinical relevance, in addition to obtaining low non-specific uptake in healthy cells, sufficient uptake must occur in tumour cells to cause cell death.
This anatomical phantom was filled with known activity concentrations to simulate SPECT imaging of T1D patients (low pancreatic uptake) and healthy humans (higher pancreatic uptake).
Similar to SPECT/CT, orthotopic U251 MG xenografts were clearly visualized non-invasively, whereas healthy mice showed negligible uptake of the tracer (Fig. 9a).
