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But it was clearly detectable in cognitively healthy study participants who were still very young between 18 and 36 years old.
A total of 2237 controls were apparently healthy study participants who remained free of CAD during follow-up.
Had this clinically healthy study population been in an actual clinical trial, 3 volunteers would have been classified as having a grade 4 ("life threatening") AE: one due to low hemoglobin and two due to elevated total bilirubin results.
This was due to a number of reasons, including a steady decline in the malaria incidence in Lambaréné area over the past decade (unpublished data), the high mobility of the local population and a study design with a close-knit passive and active follow-up system that led to the creation of an outstandingly healthy study cohort [15].
The Growing Healthy study is a randomized controlled trial (RCT).
This seems to reflect a selection toward a relative more healthy study population.
The Growing healthy study explores the feasibility of delivering such support via primary health care services.
The Growing Healthy Study tests this novel combined approach to obesity prevention.
Previous studies have either included selective healthy study samples or they have not taken potential confounders into account.
First, selection bias may have led to a relatively healthy study sample and thus an underestimation of the effect.
A potential weakness is that the Generation R cohort is slightly skewed towards a relatively affluent, healthy study population [ 30].
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