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The floating core of Charité TDR is professed to allow the replication of the kinematics of a healthy disc under physiologic loads.
Nondegenerate healthy disc material (age range, 8 to 15 years) was obtained as surplus surgical material.
PLXA2 was not detected in the healthy disc, but expressed in the degenerate disc.
Sema3A protein was expressed highly in the healthy disc, primarily localised to the outer annulus fibrosus.
The integrity of the matrix is also important for maintaining the relatively avascular and aneural nature of the healthy disc.
Sema3A may therefore, amongst other roles, act as a barrier to neuronal ingrowth within the healthy disc.
Similar(11)
Variation was 48% less in degenerated versus healthy discs (p<0.04).
However, the method currently used to harvest cells from healthy discs (disc needle puncture) has been shown to induce degeneration.
Whilst macrophages or mononuclear cells have been reported to occur in herniated extruded intervertebral discs [ 29], they are not observed in healthy discs.
Krock and colleagues demonstrated recently NGF and BDNF protein production by IVD organ cultures from degenerate disc were significantly higher than those from healthy discs [ 49].
MMP3 is an extracellular zinc-dependent proteinase involved in digestion of noncollagen matrix proteins and regulates ECM homeostasis in healthy discs.
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