Fibroblasts play an essential role in wound healing, regulation of epithelial differentiation and inflammation, and are the predominant cell type in breast tumor stroma (Tomasek et al., 2002).
PDGF is a family composed of PDGF-A, PDGF-B, PDGF-C, and PDGF-D, which are potent growth factors for myofibroblasts, and exerts their cellular effects by binding to tyrosine kinase receptors- α and - β. PDGFs play pivotal roles in wound healing, regulation of interstitial fluid pressure, malignancies, atherosclerosis, and fibrotic diseases [ 98].
Hence, the localized delivery of selected cytokines and growth factors produced by endogenous leukocytes is desirable and may have potential therapeutic values in the fundamental processes of tissue healing, growth regulation, and biocompatibility.
In addition, it contributes to tissue remodeling and healing by regulation of proteolysis, cell adhesion, migration, and survival in the injured tissue [10], [15] [22].
VTNC plays a significant role in a number of physiological and pathological processes involving cell adhesion and migration, angiogenesis, wound healing, and regulation of the plasminogen activation system [12], [13].
It plays a significant role in a number of physiologic processes such as cell adhesion, cell migration, wound healing, and regulation of the plasminogen activation (PA) system [12], [13].
Nevertheless, integrins play a crucial role in many physiological processes; for example, tissue morphogenesis, inflammation, wound healing, and regulation of cell growth and differentiation.
Also, in accordance with its principles of "salutogenesis" [ 18] and "hygiogenesis" [ 10, 43], AM attempts to specifically activate "life forces", which are considered responsible for all processes of growth, vitality, self-healing, self-regulation, adaptation and regeneration [ 10].
Macrophages can regulate three different homeostatic activities—host defence, wound healing and immune regulation.
TGF-β family members are multipotent cytokines that are involved in many cellular processes, including cell differentiation, organ development, wound healing and immune regulation.
These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis.
